克罗米酚对男性低促性腺素性功能减退症必要

洛杉矶（路透社有益版）1年初四日华盛顿邮报：据发表在12年初出版的《受孕与子代》杂志的一项简报指出克罗米胺对大多较高促性腺素性基本功能减退的男性病症险恶。来自布里斯托尔北卡罗来纳大学的该简报的第一作者Scott J. Whitten博士在接受路透通讯社专访时时说：“原发性或获得性HH病症在接受侵害性更大和更为比起的外科手术（例如药剂促性腺激素类）当年进行4个年初的克罗米胺早先外科手术是险恶的。”Whitten博士和同事研究者了克罗米胺对10名HH男性病症（HH是导致男性子代的有名状况）是否有效。简报称作克罗米胺外科手术1年后，4名沃特(德川氏)症病症中的只有一名病症的精子浓度减小而全小脑基本功能减退症病症的精子依赖症状之外没有赢取改善。无论如何，该简报指出3名成年确诊的原发性HH男性病症经过3个年初克罗米胺的外科手术精子浓度有了明显减小。现阶段该组病症已有两名维持了受孕能力。Whitten博士时说：“除非对克罗米胺外科手术没有反应，我们不会因为阿司匹林停止对病症常用该制剂。”最后作者总结时说：“因为条件有限，对HH病症促性腺激素类制剂和克罗米胺的随机研究者较难进行，然而运用多系列的严格选择标准对病症进行分级可能帮助进一步验证克罗米胺维持男性较高受孕能力的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编者：深蓝色未来世界

编者： 张靖